Sentence examples for binding and cryptic sites from inspiring English sources

The strategy underlying the Shannon splicing pipeline is to evaluate many sequence changes by information analysis quickly; this is followed by implementation of a set of heuristics based on these results combined with genome annotations to distinguish normal splice sites from those with diminished binding and cryptic sites with competitive binding affinities.

Based on these results, which suggest that the cryocooling penalty would disfavor binding at the cryptic site, and the fact that the Protein Data Bank is dominated by data collected at cryogenic temperatures,[ 5] we expected to find more δ-site binders than cryptic site binders in the previously determined structures.

Similar docking studies with an ATP-binding site-directed inhibitor suggest that it may be possible to develop hybrid inhibitors that target both the ATP and cryptic binding sites simultaneously.

Missense and synonymous mutations can alter natural splicing, create cryptic sites, and alter crucial ESE and ESS binding sites.

When high-affinity transposase binds to the Ds TIRs, binding of further transposase molecules to nearby cryptic sites may be facilitated.

Cryptic sites and alternative splicing make direct comparison of these values difficult to compute.

We assumed that the probabilities of cryptic donor and acceptor sites are the same within introns and within exons, and that only in-frame cryptic sites could be fixated as minor alternative sites.

Experimental and theoretical studies show that vinculin binding to cryptic binding sites in talin can be activated by mechanical strain [19 22], and the present results indicate that this is likely to be essential for all the VBSs in the C-terminal part of the talin rod which are contained within 5-helix bundles (Fig. 3C).

This mode is linked to more cryptic sites for TF binding.

Quantitative iCLIP data show that the RNA-binding protein hnRNP C competes with the splicing factor U2AF65 at many genuine and cryptic splice sites.

Unlike natural sites, novel cryptic sites are not under selection to maintain binding to the spliceosome, and their genomic context is less constrained than natural splice sites.