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We propose that this local structure, a helix N-capping motif, is formed upon receptor binding and constitutes a key element underlying class B GPCR activation.
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The emergence of a European Constitution, which incorporates a binding Charter of Fundamental Rights and constitutes a system of values characterised by unity and integration, demands higher quality justice and the harmonisation of criminal legislation.
Observation of nucleobase oxidative damage inducing a shape shift in secondary structure leading to protein binding and function constitutes a possible transcription factor-like quality for the NEIL DNA glycosylases binding the epigenetic-like base lesion Gh (and likely Sp).
These data provide an unprecedented overview of RNA-binding proteins and their targets, and constitute an invaluable resource for determining post-transcriptional regulatory mechanisms in eukaryotes.
Most of the epitope prediction models are based on HLA-II peptide binding, which constitutes a major bottleneck in the natural selection of epitopes.
The assumption that non-specific [11C](R -PK11195 binding constitutes a majoR -PK11195on of the signal was bindingn early in vivo studies in baboons [35].
Because MYC is a direct downstream target of WNT-dependent TCF function (via β-catenin), this pair of binding activities formally constitutes a feedback loop.
DNA binding may constitute a more widespread and underappreciated mechanism by which histone demethylases identify target regions in the genome and catalyse demethylation.
This complex binds to a 40S ribosomal subunit, followed by mRNA binding to constitute a 43S preinitiation complex.
This contrasts with our ChIP-seq data, where promoter and 5' gene region binding of FUS only constitutes a minor proportion of the FUS in situ targets.
Catalytic activity and binding categories thus constitute a hallmark of the venom gland transcriptomes analysed to date.
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