Sentence examples for binding and changes in from inspiring English sources
Insulin residues PheB25 and PheD25 are considered to be important for insulin receptor binding and changes in biological activity occur when these residues are modified.
Due to the vulnerable state of critically ill patients and altered pharmacokinetics with changes in distribution volumes, protein binding and changes in blood brain barrier, serotonergic drugs might have a greater effect on serotonergic neurotransmission than we are aware of, consequently leading to toxicity more easily.
Following ligand binding, transcription by steroid receptors is initiated by receptor-DNA binding and changes in chromatin structure contributed to by changes in histone post-translational modifications (PTMs) [12].
Indeed, very recent work has discovered significant GR binding to the genome even in the absence of ligand binding, and changes in GR binding to the genome dependent on corticosteroid concentration, underlining the complex relationship between ligand binding and target gene recognition and regulation [38].
We related Insm1 binding and changes in gene expression in coInsm1 mutant islets.
Top up-regulated genes that show significant CREB binding and changes in expression in the CREB knockdown cells.
With the sensor, we've developed a method that mimics the binding and change in the structure of the proteins, i.e. the early part of the process.
MD simulations predict large structural perturbations within very fine particles, and are consistent with experimental results showing that ligand binding and change in aggregation state can cause phase transformation without particle coarsening.
These experimental data can be fitted into an equation, and the binding constants (Kb), reaction stoichiometry (n) and thermodynamic parameters, including molar calorimetric enthalpy (ΔHobs), heat capacity (ΔCp,obs), entropy (ΔSobs) of binding and change in free energy (ΔG), can be determined accurately [156, 157].
Thus, RG13-AND2 is controlled by two input signals (ligand binding and change in redox potential) and exhibits AND gate behavior.
Additional evidence must also include chromatin immunoprecipitation assays to demonstrate "in vivo" DNA binding, and change in expression of the endogenous gene target in response to the knockdown and/or overexpression of the transcription factor.
