Sentence examples for binding and cell penetration from inspiring English sources

This study strongly supports the idea that, despite both are dendrimers of the same generation, their chemical composition might be crucial for membrane binding and cell penetration, and that a rational design of dendrimers, it means, an adequate modulation of the functional groups, could favor the development of safer and optimized carriers.

It should be noted however, that in addition to differences between TLR7 and TLR8 selectivity, differences in biochemical structures between ssRNA and the low-molecular weight thiazoloquinolone, CL075 may affect TLR-independent variables (e.g., solubility, protein binding and cell penetration) that may also contribute to distinct bioactivities.

Also included is an overview of methods that predict the binding affinity, cell penetration ability, half-life, solubility, immunogenicity and toxicity of the designed therapeutics.

We also found that the I84P mutation or the IIQ/VTR83 85 and T89A substitutions in the Vpr77 92 sequence prevent PP2A1 binding, cell penetration and apoptosis.

Triplex-forming oligonucleotides and antisense oligonucleotides share the same requirements for cellular applications, such as high binding affinity for their targets, nuclease resistance, and efficient cell penetration.

The mechanism of antiviral action of polyphenolic compounds is mainly due to inhibition of viral enzymes, disruption of cell receptors, prevention of viral binding and penetration into cells.

Phospholipases cleave host phospholipids, resulting in membrane destabilization and host cell penetration [ 71].

Our results suggest that DR5-TAT modification of Pluronic-PEI enhances transfer across the cell membrane and increases the internalization of Pluronic-PEI-DR5-TAT owing to specific ligand-receptor binding, DR5-mediated endocytosis mediated, and the enhanced cell penetration due to TAT.

Cell binding and penetration depend primarily on virion glycoproteins, but post-fusion events may depend on the tegument.

Good cell penetration and long-lasting, high-affinity binding to the RTK are required to effectively compete with the high intracellular ATP concentration [4].

Our findings indicate surface-furin binding as novel mechanism for therapeutic cell penetration which needs to be further investigated.