Sentence examples for binding and can result from inspiring English sources
The R229Q single nucleotide polymorphism in podocin (NPHS2) results in decreased nephrin binding and can result in both familial and seemingly sporadic FSGS when in a compound heterozygous state with another deleterious NPHS2 mutation [ 17].
Protein-protein interactions can occur away from the promoter and can result in the binding of complexes to the promoter (eg. ø → AB) as well as TFs unbinding as complexes (eg. AB → ø).
The process of binding and release can result in enhancement of the native state yield.
This exponent is related to the number of activator proteins that form a transcriptional complex, and cooperative binding can result in Hill coefficients larger than 1.
Flexible and combinatorial binding of TFBS can result in computational binding profiles of low specificity, which is the cause of difficulties with identification of regulatory regions embedded within long candidate regions [ 24].
The lack of eukaryotic chaperones, specialised post-translational modifications, ability to be targeted to sub-cellular locations or to form complexes with stabilising binding partners can result in protein mis-folding and aggregation.
As slow binding kinetics can result from conformational adjustments required for binding, Davis and colleagues suggested that the TCR CDR loops must undergo conformational changes upon recognition of the ligand [ 12].
However, high affinity corresponds to a strongly negative free energy of binding which can result from either enthalpic or entropic effects.
Inactivation of a ligand binding site can result from absence of an antibody chain, inappropriate assembly, misfolding, or unexpected modification of the binding site, and will affect the response ratios.
