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For example, Tsps can be engineered to have improved stability, binding and avidity with novel, narrow or broad specificities.
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This may result in enhanced binding avidity with preferential binding to cells that express both targets or binding to targets on different cells.
As the binding of a lectin to its glycan is a reversible interaction influenced by its binding affinity and avidity, we aimed to demonstrate that lectin-glycan-induced protocellular junctions can be reversed to mimic such temporary adhesiveness.
Conclusion: PRPr increases the neutrophilic phagocytosis of complement-coated particles through the action of ATP and ADP by increasing the binding avidity with iC3b, but not the number of Mac-1 (CD11b/CD18).
Sensogram data were analysed using the BIA-evaluation software version 3.1 with affinity and avidity binding constants determined using either Langmuir 1 : 1, bivalent or steady-state binding models.
Integrin clustering occurs upon ligand binding and increases binding avidity.
Monovalent binding reduces avidity and potency, thus expanding the range of mutations permitting antibody evasion.
Here, we review the accumulated evidence that the nm-scaled dimensions and conformational changes of these proteins support functions of the complement system with regard to tissue distribution, molecular crowding effects, avidity binding, and conformational regulation of complement activation.
By presenting biomolecular ligands on the surface in high density, ligand-decorated dendrimers are capable of binding to membrane receptors and cells with specificity and avidity.
Cross-linking of gp140 Env to M64U1 resulted in earlier increases of both the magnitude and avidity of the IgG binding response than those with Env protein alone.
The head-to-tail dimer configuration of affibody was previously reported to improve the affinity and avidity of EGFR binding.
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