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MftR conserves the N-terminal helix and the four residues previously shown to be involved in urate binding and attenuation of DNA binding by HucR and PecS.
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High-affinity binding and attenuation might be mutually exclusive.
In these instances, RNPC1 binding mediates a decrease in mRNA levels and attenuation of translation [ 15- 17].
Dram is short for device for the remediation and attenuation of multiple pollutants.
Size and attenuation of parotid tumours were measured.
Increasing small molecules have been found to inhibit HIF-1 activity through various mechanisms including decrease of mRNA transcription, downregulation of protein synthesis, and disrupting HIF-1 stabilization, inhibition of subunit heterodimerization, interference of HIF-1-DNA binding, and transcriptional activity attenuation of HIF-1 [ 91, 92].
UrtRs also have four conserved residues, which have been shown to be important for urate binding and the attendant attenuation of DNA binding.
Due to the short half-life of IκB, translational attenuation results in loss of NF-κB binding and subsequent expression of pro-inflammatory cytokines, as demonstrated during L. pneumophila infection [1, 19].
The propagation/attenuation zones and attenuation ability of PSMF are expressed in the propagation scenario and the iso-attenuation curves by exploiting the unit cell transfer matrix invariant.
Immunohistochemical analyses revealed inactivation of β-catenin and no attenuation of liver fatty acid-binding protein (Fig. 4c, d).
Nevertheless, given the presence of a significant component of IHERG blockade with brief depolarization and incomplete attenuation of inhibition by the Y652A and F656A mutations, we cannot exclude the possibilities that a proportion of the observed blockade with doxepin involves binding outside of the channel pore, or binding to closed HERG channels.
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