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The saturation binding analysis of this radioligand was consistent with a single population of high affinity CCK receptors (pKD = 10.24).
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Competitive binding analysis of the synthesized molecules using time-resolved fluorescence resonance energy transfer (FRET) method was carried out, and the IC50 values were determined.
Based on structure activity relationships and in silico MRSA PK binding analysis of these bisindole alkaloids, the authors designed new hamacanthin B derivatives and evaluated their antibacterial activities against drug-resistant pathogens.
Here we report a comparative binding analysis of the new ES1-derived monoclonals (14B, 14E and 5C1) and the previously described monoclonals (1D9, 1C1, 9F8 and 11F, 6A7, 6F4).
KM participated in the FcγRIIIa binding analysis of the antibodies.
However, in vitro binding analysis of the purified helicase domain, failed to show dsRNA interaction.
To further analyze the variation of the docked protein structure, we utilized MD simulation to generate a dynamic structure for binding analysis of the top three TCM compounds.
In a comparative binding analysis of the individual RIG-I domains, Vela et al. demonstrated that the CARDs antagonize RNA binding by helicase core and the CTD (Vela et al., 2012).
The fact that we could measure the enthalpies of each individual process independently and accurately allowed us to tackle the binding analysis of the ternary E2C−DBS−E2C complex by ITC.
The middle structure was chosen from each late group as a standard snapshot for the binding analysis of the top three TCM compounds: Solapalmitine (4040 ps), Isodesacetyluvaricin (4240 ps), and Budmunchiamine L5 (4340 ps) (Table 2).
Ligand-binding analysis of this protein showed in Figure 7B highlights the area of the Nop16 protein where the interaction with nucleic acids takes place.
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