Sentence examples for binding affinity within the from inspiring English sources
In particular, 2-deoxo-2-phenylflavin-5-oxides exhibited the highest potential binding affinity within the binding pocket of PTK.
For 87 out of 644 ligands, the criterion (±5%) did not result in any selected peptides because these ligands were predicted by NetMHCIIpan to be very strong binders, and no other peptides were found within the source protein with a binding affinity within the range of -5% of the reference ligand binding affinity.
2, 3 Darunavir (DRV) represents a specifically engineered inhibitor of HIV-protease, designed to have a greater binding affinity within the active site of the viral enzyme.
A single amino acid substitution (I67T) results in an increased binding affinity within the core SNARE complex, preventing the normal recycling of synaptic vesicles (36).
These include strains having different patterns of amino acid substitution in the two areas of predicted highest MHC-II binding affinity, within the principal epitope region at amino acid positions 275 285 and positions 410 445 (Fig. 7).
In particular, it is not contradictory with the insulin like growth factor receptor binding annotation known for the IGF2 human gene; in fact, the IGF2 human gene encodes both the two alternative splicing forms above mentioned [ 18], which have different binding affinity within the IGF signaling regulatory system.
The only highly significant human-specific gain of binding affinity within this island was for Rfx1 (Regulatory factor X1, aka Enhancer factor C, V$ECF_Q6), with a significant human motif binding P-value of 0.042, and non-significant chimpanzee (P = 0.635) and rhesus macaque (P = 0.491) prediction (Additional file 7).
This observation renders the redistribution of PG part of a final common pathway in ARVC pathogenesis, not merely stemming from disruptions in binding affinities within the desmosomal plaque.
The mutation causes increased binding affinities within the SNARE complex and disrupted exocytotic vesicle recycling in vivo, limiting neurotransmission under continued stimulation (76).
The Bdr Snap-25 missense mutation results in increased binding affinities within the soluble NSF attachment protein receptor (SNARE) complex, leading to impaired exocytotic vesicle recycling and exocytosis and a reduction in the amplitude of excitatory postsynaptic potentials [ 3].
