Sentence examples for binding affinity with the from inspiring English sources
The fusion inhibitory activity of the mAbs is correlated with their binding affinity with the 6-HB core.
The histidine has a positive charge on its imidazole functional group which brings about changes in the binding affinity with the metal nanoparticles (Flora and Pachauri 2010).
We designed a series of compounds based on a quinazoline scaffold pharmacophore model which may have high binding affinity with the p50 subunit of NF-kB.
Further, SAR and docking studies suggest that in comparison with the α,β-unsaturated derivatives, the saturated carboxylic acid derivatives had a greater binding affinity with the enzyme and thus an enhanced inhibition activity.
Furthermore, the shFcRn exhibited about 10-fold higher binding affinity with the tumor necrosis factor-α antagonists of monoclonal antibodies Infliximab and Adalimumab than that of Etanercept, providing a clue to their different serum half-lives in vivo.
The traditional drug design strategy centrally focuses on optimizing binding affinity with the receptor target and evaluates pharmacokinetic properties at a later stage which causes high rate of attrition in clinical trials.
To directly compare rhTF's TFR binding affinity with that of hTF, the TFR binding capacity (Bmax) and equilibrium dissociation constant (Kd) values of both rhTF and hTF were determined using saturation radioligand binding assays in HeLa cells.
Only two compounds have an associated binding affinity with this target and hence the target did not meet the requirement of having data for at least 20 compounds.
The results indicate that the mutated protein BbpT582A or BbpL584A exhibits higher binding affinities with the peptide than wild type (WT) Bbp273−598 protein.
Compounds 5d, 5e, and 5i found to be most potent with IC50 in the range of 0.09 0.19 μM and 0.03 0.04 μM against the Dd2 strain and 3D7 strain respectively as well as they showed good binding affinities with the residues of the active site of pf KASI/II.
