Sentence examples for binding affinity with an from inspiring English sources
These models predicted human corticotropin releasing factor-1 receptor binding affinity with an accuracy of ≥85%.
The results of the saturation curves imply that ATP accessibility to the single-stranded region is critical to the experimentally measured binding affinity with an observed tunability over 4 orders of magnitude.
Analysis of the results from this experiment (Table 2) revealed that the N32D mutation caused the greatest increase in ATP binding affinity, with a Kd of 360 nM, relative to protein 18-19, which binds ATP with a Kd of 1100 nM.
Among the synthesized compounds, N-2′-chlorobiphenylylmethyl 2-methoxyphenylpiperazinylpentanamide 1 8 showed the best binding affinity with a Ki value of 8.69 nM and it was verified as a novel antagonist according to functional assays.
In addition the substitution analysis indicated which amino acids were most preferred at anchor residues in the lead peptide, generally leading to an increase of binding affinity with a factor of 2. Next we tested which combinations of such preferred amino acids yielded the best results.
The average affinity of a drug/target captures their typical binding behavior, which is valuable to predict the binding affinity with a specific target/drug.
To investigate if these findings could be applied to improve the in silico identification of MHC class II ligands, a simple model was created which integrated the MHC-II binding affinity with a structural feature or surface exposure as described by Eq.(1).
This model predicts that each subfamily has a characteristic structure and mode of determining binding affinity with a ligand.
Competition binding studies demonstrated that ondansetron also has high 5-HT3 receptor binding affinity, with a Ki value of 0.47 ± 0.14 nM.
