Sentence examples for binding affinity while the from inspiring English sources
We found that the phosphate group of FUNDC1 pS17 binds to LC3B Lys49 and enhances the binding affinity, while the phosphorylation of FUNDC1 Tyr18 may conflicts with the hydrophobic pocket of LC3B and disrupt the interaction.
As evident from results the OH group of ring A is not involved in hydrogen bonding and therefore its absence in case of 5a increased the binding affinity, while the ortho hydroxyl group of ring B increased binding affinity as it is involved in hydrogen bonding with the target.
The input of the semi-quantitative SVR model is the encoded representation of the PDZ domain peptide pair (see below) and the corresponding binding affinity while the output is the predicted affinity score for each pair.
Our work was based on the premises that the inverse agonist cyclopeptide T140 will provide binding affinity, while the grafted N-terminus chain will provide agonist properties, in line with the two site model suggested for SDF-1-CXCR4 interaction.
Thus, insulins and analogues that reach equilibrium quickly will appear to have a potency proportional to their binding affinity, while those with slow kinetics like hagfish and lamprey insulins will have potencies that appear to be proportional to their association rates.
Moreover, cleavage of chemokines by MMPs has been shown to generate chemokine receptor antagonists that retain cellular binding affinity while inhibiting the biological activity of the receptor [ 43].
The complex with all modifications yielded a lower score compared to the 14-3-3ζ 14-3-3ζ 14-3-3ζ complex, indicating tH3Ser10PLys14Acation decomplex the bindicatinginithathiLys9ys14 acetylation increase the bindecreasesnitheof the phosphorylated peptide.
These studies unexpectedly revealed quite a flat nanomolar/subnanomolar SAR for the binding affinity, while differences were seen in the in vitro functional activities.
Controlled/living polymerization techniques were used to synthesize recognitive poly methacrylic acid-co-ethylene glycol dimethacrylate) (poly MAA-co-EGDMA)) networks which resulted in a 63% increase in the number of binding sites at apoly MAA-co-EGDMAvalent average binding affinity while retaining selectivity of the target molecule, ethyladenine-9-acetate.
Replacement of ACTT in RD6 with CCTT or ACGT modestly reduced the binding affinity, while replacement with ACTG or ACGG drastically reduced binding affinity (Table 1, RD6m22 and -24 26).
Phage P61, which was the was most frequently picked up in the panning experiments, displayed the highest relative binding affinity, while phage carrying peptides P21, P22, P62, P64, P65 and P67 showed intermediate affinities.
