Sentence examples for binding affinity which inhibits from inspiring English sources

We used phage-display peptide screening to identify a tetrapeptide showing moderate binding affinity, which inhibits the interaction between Nrf2 and Keap1.

However, MrkH116-end loses the c-di-GMP binding affinity, which indicates that the connecting loop between two β-barrels is crucial for c-di-GMP binding.

A recent study showed that phosphorylation of Twist1 affected its dimer affinity for a given partner and modulated the DNA binding affinity, which might control limb development [10].

In the present paper, we have applied this engineering process to CXCL8 and after three mutation rounds we ended up with a structurally stable, dominant negative protein, CXCL8 Δ6F17KF21KE70KN71K), which exhibited a 5-fold improvement in GAG-binding affinity and which inhibited neutrophil recruitment into inflamed joints as well as hypernociception in vivo.

Our study reveals that IFNAR1 flexibility modulates ligand-binding affinity, which, in turn, regulates biological signaling.

To determine if the Arl2 GTPase is responsible for increasing the TBCC binding affinity to TBC-DEG, we next generated a Gln73Leu (Q73L) mutation in Arl2, which inhibits GTP hydrolysis and results in a 'GTP-locked' state (Veltel et al., 2008).

Recent research suggests that technical knowledge is often not the binding constraint to development, but rather the lack of good governance which inhibits public-service delivery.

BMP-9 binds to activin receptor-like kinase (ALK1) with high affinity which effectively inhibits angiogenesis.

These findings are confirmed by binding affinity calculations which are in good agreement with experiment.

Importantly, ADP binds with low affinity, which is insufficient to interfere with binding or release of these high affinity inhibitors.

It is feasible that high levels of phytoestrogens, which have low potency (Table 1) and low estrogen receptor binding affinity, may have effectively inhibited activity in the YES by competing with potent estrogens for receptor binding sites.