Sentence examples for binding affinity which decreases from inspiring English sources

However, these molecules may exhibit lower receptor binding affinity, which decreases the in vivo activity and limit the benefit of longer half-life.

Moreover, the theoretical binding affinity represents the trend of the experimental binding affinity well, which decreases as the size of the metal cation gets larger or smaller than that of K+[34].

Saturated fatty acids decrease responsiveness of the cell membrane to insulin-mediated actions through a decrease in binding affinity, which contributes to increased insulin resistance (28).

Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA.

DFT calculations support loss of water driven by binding of the strong donor acac, which decreases water affinity by ∼2.8 kcal.mol−1.mol−1

However, HIV-1 develops drug-resistance which decreases the affinity of Nelfinavir for the binding pocket of Protease.

An increase in blood CO2 decreases pH, which decreases hemoglobin affinity for oxygen (Bohr Effect).

The S308V mutantmutant (a mutation which decreases cGMP selectivity in eukaryotic channels) decreased both the observed cGMP binding affinity and the sensitivity to cGMP relative to the wild-type (WT) channel, leaving those for cAMP unchanged.

PHD1KDM5A binds the N-terminal tail of histone H3 with a preference for unmodified H3, and binding affinity decreases with an increase in H3K4 metH3K4tion40.

For highlighted lines which are parallel to the axis for KDA, "bell" shaped profiles for HGB peak concentrations can be observed when the receptor binding affinity decreases (KDA value increases).

N59D uniquely causes PEP binding affinity to decrease, while having little effect on the binding affinity of MgADP.