Sentence examples for binding affinity which contributes from inspiring English sources

Saturated fatty acids decrease responsiveness of the cell membrane to insulin-mediated actions through a decrease in binding affinity, which contributes to increased insulin resistance (28).

Binding affinity comparisons suggest that the p-hydroxy group on the benzoate ring, which contributes most to the binding, is playing the role of the phenolic hydroxyl of estradiol.

Based on the complex structure of mPD-1/hPD-L1, Mautetet al. have taken advantage of directed evolution of the amino acids in hPD-1 which contributes to the binding with PD-L1 by yeast-surface display to engineer the PD-1 ectodomain as a high-affinity (110 pmol/L) competitive antagonist of PD-L1 (Maute et al., 2015).

Several studies suggest that high-affinity antigen binding drives naïve B cells to differentiate into short-lived, isotype-switched plasma cells (PCs) within the extra-follicular region which contributes to the initial control of infections.

Instead of a continuous binding epitope, three so-called interaction clusters could be identified, which contribute affinity independently and might therefore allow for a scalable affinity to different cytokine ligands [ 34].

The transcriptional repressor REST (NRSF), which encodes DNA binding affinity hierarchies contributing to regulation during lineage-specific and developmental programs, provides another example (9).

The permuted population plots show the average predicted MHC binding affinity at each position, a quantitative measure; they do not show which alleles are contributing to the binding and thus do not reflect the qualitative sequence differences which contribute to the separation seen in the scatterplots in Figure 2.

N-terminal tyrosine sulfate residues and threonine O-linked glycans are high affinity binding sites for P- and L-selectin to human and mouse PSGL-1 [ 16- 18, 20, 44- 46], which contribute to stabilize leukocyte rolling [ 16].

Importantly, ADP binds with low affinity, which is insufficient to interfere with binding or release of these high affinity inhibitors.

The double mutant acquired a significant binding affinity to cellulose, which was lacking in wild-type P. furiosus chitinase, without the loss of affinity to chitin.

Thus, the superior DNA binding affinity of hPolη likely contributes to its dominance within the four enzyme combination assays.