Sentence examples for binding affinity was reduced from inspiring English sources
On the other hand, the docking scores for the susceptible drugs, ponatinib and axitinib, remained higher, although binding affinity was reduced by 20 and 5% for ponatinib and axitinib, respectively.
Similar results were obtained for TGA, where the binding affinity was reduced by 15-, 39-, 180-, and 40-fold in binary, dATP, dGTP, and dTTP, respectively (Table 3).
Upon UV light impact also the binding affinity was reduced on both polymers and it was again more significantly affected in the imprinted polymer.
When the first motif, TCACAGC (superscripts indicate the positions of the base in the direct repeat), of RD6 was substituted with GGCGCTG (RD6m1 in Table 1), the binding affinity was reduced ∼40-fold with an N of ∼1.
Binding affinity was reduced more than 100-fold for Y43A, 20-fold for L39A and 10-fold for A46N, all in accord with their apparent roles in Gemin2-binding.
Lipid A binding affinity is reduced almost 5-fold when it binds after daunorubicin.
While SR RS2) is a substrate for both kinases, the binding affinity is reduced compared with the wild-type kinase since we were unable to saturate the kinases in plots of initial velocity versus substrate.
This large difference in the DNA-binding affinities was reduced to only 4-fold in the presence of 0.15 mM of Mn2+.
When there were more than three G or C residues in the spacer, the binding affinity was significantly reduced (Table S1 of the Supporting Information).
In contrast, the basal activity of the mutant with the clamp locked open was unchanged; its activation by SecYEG was reduced and the binding affinity was unaffected.
Our results suggest that while the binding topography does not significantly change with the additional phosphorylation, the binding affinity is considerably reduced by 12- and 30-fold for ppSpry2 and ppEGFR, respectively.
