Sentence examples for binding affinity was increased from inspiring English sources

A repebody specifically binding to human TNF-α (hTNF-α) was selected through a phage display, and its binding affinity was increased up to 49 nM using a modular engineering approach.

Interestingly, FOXA1 binding affinity was increased for the [T] variant allele compared with the [C] reference allele.

Conversely, if θ<0 then dφ/ dk<0, and therefore ϕ will decrease when the binding affinity is increased.

Such a loss of protein motion may also provide an explanation for how calcium-ion-binding affinity is increased upon binding a target.

The affinity was increased post-hydrolysis, but the initial high-affinity binding was only restored following release of inorganic phosphate.

The membrane binding affinity was slightly increased on the PI 4,5 P2-present membrane PI 4,5 P2-presenthe membraneency of the possibly2 headueoup and/or increased membrane penetoathen driven by PI(4,5)P2.

The impact upon calculated binding affinity was minimal, increasing the KD describing N peptide-HSP72 interactions to only 4 μM, a value that remains within the range of activity control reactions.

Isothermal titration calorimetry (ITC) data reveal that the heparin binding affinity is significantly increased when the charge on D82 is reversed but not when the negative charge is reversed at both positions D82 and D84 (D82R/D84R).

In case of RGPD/HMPR double mutant, an increase in binding affinity was observed compared with the original mutants (Table 2).

Bivalent interaction of the aptamer assembly with thrombin, which increases overall binding affinity, is proposed as the mechanism for the enhanced inhibition.

The observed increase in binding affinity is likely due to removal of potential alternative competing structures, thus allowing a tighter interaction between the protein and the RNA.