Sentence examples for binding affinity towards the from inspiring English sources
These bifunctional ligands showed very good binding affinity towards the both μ and δ opioid receptors.
The optimization of lead compounds as viable drug candidates involves the optimization of their binding affinity towards the selected target.
In particular, the focus here is on immobilization technologies of recombinant antibody fragments utilizing affinity peptide tags, which possesses strong binding affinity towards the ligand molecules.
In this work, we investigate the influence of the site at which the chelator NODAGA is attached to exendin-4 on its binding affinity towards the GLP-1 receptor.
Whether the subtle difference in protein structure between zfPRL1 and zfPRL2 would result in differential receptor binding affinity towards the two receptors or in their preference for signaling pathway usage awaits further experimentation.
However, structural transformation of human insulin might also result in different binding affinity towards the insulin-like growth factor-1 (IGF-1) receptor (IGF1R).
Flavonoid glycosides exhibit higher binding affinities towards the DNA triplexes than their aglycone counterparts.
Fifty molecules were designed and included in the in silico analysis to evaluate their druglikeness and binding affinities towards the selected target proteins using various pharmacokinetic and docking software.
As the differences in the binding affinities towards the respective ligands of K63-Ub2 are caused entropically, the difference in conformational free energy should be equal to the difference in binding free energy.
Meanwhile, 1- 2-hydroxyphenyl -4-methylpentan-1-one and 4-methylpentyl benzoate also showed fairly good binding affinities towards the target protein BRCA2 with a G score of −4.5 and −3.8, respectively.
For comparison, SG was also titrated with λDNA and Tbr DNA, respectively, in 100 mM Tris pH 8.0, and the resulting normalized titration curves were co-plotted with those of EG. Unlike EG, SG displayed differential binding affinities towards the two types of DNA; the significant left-shifting of the SG titration curve with λDNA suggests that SG has a higher affinity toward λDNA than toward Tbr DNA.
