Sentence examples for binding affinity to target from inspiring English sources

The results showed that the 2′-O-methyl modified DNA can improve stability, increase binding affinity to target strands and enhance the therapeutic effects.

Our approach is to split one single strand aptamer into two pieces and each terminally labeled with a pyrene molecule while maintaining their binding affinity to target molecules.

Thus, we can conclude that the binding affinity to target proteins does not always concur with the chaperone activity data.

These two categories of phages are then present in the data, regardless of their actual binding affinity to target molecules.

The altered protein structure of the CFH Y402H "at risk" variant results in a decreased binding affinity to target molecules such as C-reactive protein and heparin to cell surfaces and Bruch's membrane [ 16, 44– 50].

Although the acetylation of several TFs such as p53 and MyoD has been connected to their DNA-binding activity at target gene promoters, the acetylation of SOX family proteins has been reported to affect cellular and nuclear localization rather than controlling of binding affinity to target gene promoters.

In this study, we propose a computational method to infer miRNA effective activity by integrating their binding affinities to target genes with gene expression changes measured by microarray experiment.

First, they can improve the sensitivity of detection through synergistic increase of binding affinities to targets.

Experiments have shown that D-and L-amino acid versions of antimicrobial peptides exhibit similar binding affinities to targets cells, suggesting that stereospecific receptors are not involved in targeting pathogenic cells [ 9].

Here, the three most promising candidates: R28K, R201A and R201K and an additional one previously described in literature, K27A, were compared with the wild-type protein for binding activity and affinity to target cells and serum stability of the protein.

The RNA molecules are then selcted based on their binding affinity to the target molecule, for example, by passing them through a target-immobilized affinity column.