Sentence examples for binding affinity to human from inspiring English sources

Lebrikizumab is a novel humanized stabilized immunoglobulin G (IgG) four monoclonal antibody exhibiting high binding affinity to human IL13 6. Lebrikizumab was demonstrated to be effective in improving prebronchodilator forced expiratory volume in 1 s (FEV1) in patients with uncontrolled moderate severe asthma 7.

Transfection of human 293 fibroblast cells with the marmoset prolactin receptor cDNA (three independent experiments) confirmed the expression of a receptor that has high binding affinity to human growth hormone (Ka=3.6±0.07 nM−1 and Bmax=7.55±2.06×10−11 M) and human prolactin (Ka=3.1±0.12 nM−1 and Bmax=2.87±0.66×10−11 M).

We labeled belatacept with the gamma-emitting nuclide indium-111 (physical half-life 2.8 days) and characterized its binding affinity to human CD80/CD86 and its stability in plasma in vitro.

Of the 250 compounds in the database, 220 have been tested for their binding affinity to human TTR.

A PCA was applied to view the chemical variation of the 220 compounds tested for their binding affinity to human TTR.

Although Tbp1p does not appear to play a role at telomeres, it has a binding affinity to human type telomeric DNA.

In silico-guided designed hit molecules were then synthesized and tested for their binding affinities to human AT1 receptor in radioligand binding studies, using [125I-Sar1-Ile8] AngII.

The relative binding affinities to human aldose reductase (ALR2) of three new 7-hydroxy-2-benzyl-4H-1-benzopyran-4-one inhibitors were predicted by free energy perturbation (FEP) simulations.

Both Lexicon antibodies have potencies below 500 pM as determined by binding affinities to human DKK1 (416 pM for Ab #1 and 347 pM for Ab #2) and mouse Dkk1 (128 pM for Ab #1 and 233 pM for Ab #2) and IC50 values (270 pM for Ab #1 and 370 pM for A b#2) in a mouse cell-based assay employing Wnt3a as a stimulator of Wnt signaling.

DOTATOC labeled with 68Ga showed high binding affinity to the human somatostatin receptor subtype 2, improving tumor imaging capabilities and offering the possibility of low dose imaging followed by higher dose treatment.

Among the various factors that influence the efficient viral transmissibility in humans we have shown in both the 1918 pandemic H1N1 and the recently declared 2009 pandemic H1N1 that the binding affinity to the human receptors (quantified using Kd') correlates with the transmissibility of the virus via respiratory droplets in ferrets [19], [21].