Sentence examples for binding affinity to be from inspiring English sources

Recent studies, especially on model receptor systems, have clarified many of the challenges that must be overcome for robust predictions of binding affinity to be useful in rational design.

But very few transcription factors (TFs) have been experimentally characterized well enough to know which of the vast number of potential binding sites have sufficient binding affinity to be used as regulatory sites in vivo.

This stability in free solution allowed for its binding affinity to be tested over the same time period.

Values of DNA binding by thermal melting (Δ T m, measured as described in reference 15) revealed the binding affinity to be greater than that of pentamidine (12.6°C) but lower than that of DB75 25°CC) (Table 1).

More recently, Annala et al. [ 21] proposed a linear model (HK →ME) that assumes the binding affinity to be the sum of the contributions of certain subsequences of the binding sequences.

The use of the AuNP-FAM energy transfer pair allows the binding affinity to be measured and the change in distance following ATP binding to be monitored using nanometal surface energy transfer techniques.

Notably, there was a trend for the experimentally-measured peptide binding affinities to be slightly higher than the values predicted by the model; potential reasons for this are discussed below.

Lastly, it follows that any small-molecule inhibitor bound to Ca2+ S100B would also have to cause an increase in calcium-ion-binding affinity to be effective therapeutically inside a cell, so these data need to be considered in future drug design studies involving S100B.

Furthermore, by studying the effect of the ligand on the second-order refolding reaction, we found results indicating similar PGA-binding affinities to be present in the transition states for the rate-limiting steps of the forward and backward reactions.

These two selected sequences with higher binding affinity to Ang2 were all generated from Seq15, and the best one was Seq15_12_35.

While RRASWT was found to bind to RAF1, RALGDS, RASSF5 and PLCE1 less efficiently than HRAS, an increased binding affinity to PIK3CA was observed.