Sentence examples for binding affinity to apoptotic from inspiring English sources
The binding affinity to apoptotic cells of the anxA5-DTPA conjugate does not differ from that of wildtype anxA5.
iASPP has a higher binding affinity to p53Pro72 than to p53Arg72, and preferentially modulates the apoptotic potential of p53Pro72 over p53Arg72.
Previous studies in tumor models revealed that the expression of anti-apoptotic Bcl-2 proteins with a low binding affinity to ABT-737, such as A1 and Mcl-1, resulted in resistance to this compound.
Cells undergoing apoptosis or necrosis can be detected with annexin A5, which is a cellular protein with binding affinity to the phospholipid phosphatidylserine (PS), which is increasingly exposed on the surface of apoptotic and necrotic cells.
Because anti-apoptotic Bcl-2 family proteins participate in complex pathways with many components, the qualitative and quantitative differences in function for Bcl-2 and Bcl-XL may be mediated by altered binding affinity to other proteins that affect apoptosis (including but not limited to pro-apoptotic Bcl-2 family members, as has been recently reported, 46).
On the other hand, Hg2+ showed strong binding affinity to fresh DOM (L-1) and binding affinity decreased as the age of leachate increased.
Lower p53 binding affinity to promoters has been invoked by others [66], [67] to explain the rapid induction of cell cycle genes (within 2 hrs) compared to the intermediate-to-late induction of apoptotic genes (4 to 8 hrs) post-irradiation.
The early apoptotic cells tend to exhibit phosphatidylserine on outer cell membrane, which is normally positioned across the inner membrane [ 35] and it has a strong binding affinity to annexin V [ 36].
