Sentence examples for binding affinity that occurs from inspiring English sources

Importantly, the concentration of radioligand used was sufficiently high to overcome the minor changes in radioligand binding affinity that occurs in human CNS tissue [ 25] ensuring this approach gives a good estimation of total binding sites within the tissue [ 26].

Since in practice there is poor knowledge of the rate constants and binding affinities that occur in F (c), we are primarily interested in assessing a network's capacity for multiple equilibria or bistability without specifying these parameters, though all rate constants are assumed to be positive.

The first is a hairpin polyamide structure (representing the DBD), which was specifically chosen because of its high specificity to target DNA sequences and exceptionally high binding affinity that is comparable to naturally occurring DNA-binding proteins.

Each predicted binding pose is assigned a binding affinity that can be calculated using a variety of scoring functions.

Because progesterone and cortisol bind to CBG with about equal affinity [ 84], the exponential rise in circulating progesterone that occurs in late gestation competes with cortisol for CBG binding sites, dynamically affecting the bioavailability of both hormones.

For example, a variation that occurs in a gene known as ALAD (delta-aminolevulinate dehydratase) results in the production of an enzyme called ALAD2, which has an abnormally high binding affinity for lead.

Our data present evidence that the binding affinity of TR for DNA might be affected by modifications that occur in the LBD after ligand binding, without disrupting the oligomerization state of the protein.

Overall, this selection strategy yielded three crossreactive antibodies that occurred at lower frequency within the total selected variant pool and had weaker binding affinities compared with the mono- and bi-specific antibodies.

Water is treated as a co-reactant for unfurling the affinity studies in ZFP-DNA binding equilibria that takes into account the unavoidable change in hydration that occurs when these two solvated surfaces come into contact.

Affinity measurements using related PC-phenyl analogues, including peptides of varying lengths, demonstrate that carrier determinants contribute to binding affinity and that somatic mutations alter this recognition.

Receptors are proteins that have specific binding affinity for substances that produce a physiological event in the body.