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Overall, this resulted in a binding affinity that is quite similar to that in aqueous solutions.
The structural conformation and physicochemical properties of both the ligand and its receptor site determine the level of binding affinity that is observed in such an interaction.
However, those values evidence a very good binding affinity that is illustrated in Figures 6B and C. In the present work, we have structurally characterized the two components of the catalytic reaction core.
Fulvestrant competitively inhibits binding of oestradiol to the ER, with a binding affinity that is 89% that of oestradiol (Wakeling and Bowler, 1987).
The first is a hairpin polyamide structure (representing the DBD), which was specifically chosen because of its high specificity to target DNA sequences and exceptionally high binding affinity that is comparable to naturally occurring DNA-binding proteins.
Overall, the inability of the three pterin analogues to form hydrogen bonds with S104 and F462 and the steric clashes from their protruding methyl groups may be attributed to a binding affinity that is poorer than that of the native pterin, H4B.
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The derivative in which d-Ala of argifin was replaced with d-Trp appeared to possess a binding affinity that was equally potent to that of argadin.
[AibB5]-insulin had a binding affinity that was 4.4% of that of HI.
We only considered drug-target annotations with binding affinity that were lower than 10 μM [ 15].
The selectivity of [F]FProp-C*RRETAWAC*-OH was comparable to that of the lead structure with high binding affinity that was found for integrin α5 β1 and low binding affinity for integrins α v β3 and α IIb β3.
Therefore in order to monitor changes in the recent avian H2-subtype viruses that would possibly lead to their human-adaptation, it is important to understand the mutations in their HA that would confer human receptor-binding affinity that is quantitatively in the same range as that of HA from the 1957-58 human-adapted H2N2 pandemic viruses.
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