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Moreover, it was shown the properties of the particles synthesized at optimum conditions had binding affinity similar to monoclonal antibodies.
The pyridazinone exhibits a binding affinity similar to those of tolrestat and sorbinil, and shows slightly reduced affinity compared to IDD 594.
Our data showed that the ccFv molecule had a binding affinity similar to the corresponding scFv but was significantly improved in thermostability and phage display level.
A fully human IgG antibody, MT-201 combines binding affinity similar to Ederecolomab with considerably enhanced ADCC potency with human gastric carcinoma cell lines.
In our analysis, zanamivir had a binding affinity similar to that of sialic acid, with docking energy of −12.84 kcal/mol (Table 1).
The EC AEA is an agonist at TRPV1 with a binding affinity similar to that of the hot pepper ingredient capsaicin, although it does not activate the receptor like capsaicin [ 56].
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Energetic analysis points out that lapatinib and TAK-285 have better affinity for inactive EGFR than the active EGFR state or HER2, whereas some EGCG derivatives seem to form binding affinities similar to those observed for lapatinib or TAK-285.
Are other acidic patch binders post-translationally modified to tune their binding affinities similar to HMGNs?
Murine anti-Ep-CAM mAb M79 (Gottlinger et al, 1986) and anti-HER-2 mAb 9G6 (van de Vijver et al, 1988) were selected because they had binding affinities similar to MT201 and trastuzumab, respectively.
In-line probing control experiments show that labeled riboswitches exhibit patterns and glycine binding affinities similar to those of the wild-type construct (full details provided in the Supporting Information).
Interestingly, systematically increased hybridization signals (with respect to the averaged hybridization signal level from other defect types at the same position) have also been observed for certain Group I bulges: For G-insertions next to a T (e.g. in Fig. 5 at base position 15) we frequently find increased binding affinities similar to that of Group II bulges.
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