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Thus, a link to BindingDB was added on the ligand webpage, and one can find the reported data on binding affinity on the linking page.
With increasing V V) content, the Pb2+ binding affinity on the V-doped birnessites significantly increases, ascribing to both the formation of the vanadinite precipitates and decreased particle sizes of birnessite.
Incorporation of the operational model into the PK/PD modeling of ESAs allowed us to dissect the influence of receptor binding affinity on the drug effect, and to quantify the intrinsic efficacy of the erythropoietic system from in vivo data.
At present the impact of these differences in binding affinity on the interpretation of the PET signal remains to be fully elucidated although it may be expected that low-affinity binding sites should lead to an underestimation of TSPO.
Given the influence of receptor binding affinity on MEC, we incorporated the formalism of the operational model of agonism in the PK/PD modeling and simulation of ESAs, to dissect the influence of receptor binding affinity on the drug effect, and unravel the intrinsic efficacy of ESAs from clinical data.
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For example, sensitivity analysis provides information on the effect of changes in parameters (such as binding affinities) on the state of model variables (such as the phosphorylation of key protein).
The binding affinity of the hapten on the inhibitor was thus enhanced relative to the hapten on the HtTA due to the polyvalent interaction, and this was sufficient to block the cross-linking of IgE by the HtTAs.
This is to take into account the amplification effect of cytosolic calcium on binding affinity of the receptors.
The effect of metal ions on the kinase activity depends on the binding affinity of the enzyme to metal-ATP complex.
The mechanism of receptor trafficking and dimerization is taken into account to exert positive feedback effects on the binding affinity of the cognate receptors.
A competitive radiolabeled receptor binding assay was used to determine the binding affinity of the cRGDfk peptide on the QD surface to ABIR.
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CEO of Professional Science Editing for Scientists @ prosciediting.com