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Mechanisms of binding and the relative binding affinity of various BPs to bone mineral are introduced, including common methods for measuring binding affinity in vitro and in vivo.
Due to different binding mechanisms, the binding affinity of various TSPO radioligands may vary significantly.
Fig. 1 Structures of three focused OBOC libraries and binding affinity of various peptide ligands for α3β1 integrin-expressing glioblastoma cells by flow cytometry.
Indeed, in a previous work we demonstrated differences in the binding affinity of various HSPB1 mutants according to the localization of the mutation in the protein [ 5].
The binding affinity of various CBD peptides to CaM reflects their inhibitory potency on eNOS oxygenase activity as well as reductase activity.
However, further studies are necessary to investigate whether the polymorphism whether alters the binding affinity of various partners and/or regulates Arc's response to various cytosolic environments.
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If the structural properties of the receptor site are known (for example, there is crystallographic data) then techniques involving approximations of potential functions can be applied to estimate or at least compare binding affinities of various ligands [1].
Table 1 summarises and compares the binding affinities of various peptides derived from the hTectonin and GBP.
Transcription factor binding data was taken from Harbison et al. [ 24], which includes the binding affinities of various TFs to all promoters in YPD medium.
The binding affinities of various bisphosphonates have been shown to vary according to differences in the R2 side chain (zoledronate > alendronate > ibandronate = risedronate) (Nancollas et al 2005).
Nancollas et al 42 demonstrated that the different binding affinities of various bisphosphonates correlated with the differences in the R2 side chain (ZOL > alendronate > ibandronate = risedronate).
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