Sentence examples for binding affinity of transcription from inspiring English sources

Through reduced binding affinity of transcription factors to this region (for example, Ets-1), miR-146a expression was reduced [ 47].

A single nucleotide change enhances the binding affinity of transcription factor HOXB7 and results in downregulation of DAPK1 transcription.

These epigenetic mechanisms can affect the binding affinity of transcription factors to the miR-21 promoter regulating its expression level.

Evidence is surmounting that DNA methylation can modify the binding affinity of transcription factors to DNA to fine-tune gene expression regulation.

These SNPs have wide range of frequency (∼0.001 0.48) in the population and could influence the rate of gene expression by modifying the binding affinity of transcription factors.

d'Alesio et al. (2005) detected that several SNPs are predicted to be related to genes by influencing the binding affinity of transcription factors in the promoter region.

Thermodynamic models are useful when there is existing knowledge about the promoter structure for the gene allowing binding affinities of transcription factors to DNA as well as combinatorial control to be incorporated.

Mutations that alter the binding affinity of a transcription factor are therefore likely to be pleiotropic and, consequently, deleterious in most cases.

To date, lack of myogenic differentiation of PAX3-FOXO1 expressing ARMS cells has been attributed to their inability to upregulate p57Kip2 activity, hence destabilizing the DNA binding affinity of MYOD transcription complexes.

That is, they alter the binding affinity of a transcription factor (TF) to the DNA, which in turn alters the expression of certain genes, consequently contributing to the disease phenotype.

A total of 96 069 promoter SNPs were identified; 10 000 were randomly selected as the background when generating the empirical P-values for the significance of effects on binding affinity of each transcription factor.