Sentence examples for binding affinity of tau from inspiring English sources
The tau V337M) variant reduces binding affinity of tau to microtubules, accelerates tau aggregation, and leads to age-associated paralysis (Kraemer et al., 2003).
This result shows that ubiquitin-modification of tau by the axotrophin RING-variant domain leads to a decreased microtubule binding affinity of tau.
Whereas multiple mono-ubiquitination of tau by axotrophin could be a physiological event regulating microtubule binding affinity of tau it may also provide the basis for ubiquitin chain elongation by so called E4-ligases.
PAR-1/MARK-2 (mammalian homolog microtubule-associated protein/microtubule affinity-regulating kinase 2) has been shown to phosphorylate tau at the S262/S356 sites, causing a significant reduction in binding affinity of tau for microtubules (26).
The multiple mono-ubiquitination of tau by the RING-variant domain of axotrophin suggests that the microtubule binding affinity of tau is affected by tau ubiquitination.
It is likely that the molecular weight of heparin affects its binding affinity to Tau fibrils, with higher molecular weight species exhibiting increased affinity.
It has a unique binding affinity for tau phosphorylated at disease-specific phospho-epitopes, and is required for the ubiquitination of these tau species, leading to their proteasome-mediated degradation (6– 8).
However, the binding affinity of PDZ domains is known to be regulated through allosteric interactions49.
The binding affinity of 4-[18F]FEBZA wassessedsed using a homologous competitive binding assay.
Due to different binding mechanisms, the binding affinity of various TSPO radioligands may vary significantly.
