Sentence examples for binding affinity of such from inspiring English sources

This work reports a Quantitative Structure Activity Relationship (QSAR) study for predicting the binding affinity of such type of compounds towards the A3 AR.

The heat of formation (HF) and log P are recognized as the most important descriptors for binding affinity of such compounds to BzR.

A SERS based optical sensor has been developed in order to detect and quantify the prion proteins (PrPC) onto the cell membrane using the higher binding affinity of such proteins for copper ions.

The number and binding affinity of such cis-binding elements provide a mechanism of transcription regulation [ 1].

Moreover, it is unlikely that attenuation of IKKβ binding affinity of such similar magnitude would occur with two disulfides at such different locations within the NEMO structure.

To achieve higher binding affinities of such Ras Raf interaction inhibitors, zinc II cyclen conjugates with short peptides, derived from the sequence of the Ras-activator SOS, were prepared by solid phase synthesis protocols.

Three GPCR accessory proteins called receptor activity-modifying proteins (RAMPs) modify the ligand binding affinity of the receptor such that the CLR/RAMP1 heterodimer preferably binds CGRP, while CLR/RAMP2 and CLR/RAMP3 have a stronger affinity for AM.

It appears that mutations near the heme cofactor of CYP51 reduce the binding affinity of compact azoles, such as fluconazole and itraconazole, and may lead to azole crossresistance.

A molecular docking method is defined as the prediction of both the binding mode and binding affinity of a query ligand (such as a small-molecule drug) against a receptor (such as a target protein) (Brooijmans and Kuntz 2003; Sousa et al. 2006; Grinter and Zou 2014a, b).

Functionally, p-p47 acts as an adaptor protein helping to increase the binding affinity of other NOX components, such as gp91 and p22 (Babior 2004).

This accounts for the generally weaker binding affinity of simple amino acids such as l-valine, l-ornithine, and l-lysine, which do not interact directly with the active site Mn2+ ions.