Sentence examples for binding affinity of small from inspiring English sources

QSAM attempts to quantitatively model the binding affinity of small peptide drugs to macromolecular targets, similar to QSAR in the field of small molecules.

Quantifying the binding affinity of small molecules to a polymeric film is very important in understanding the adsorption phenomenon in food industry.

Among these, computational methods able to predict the binding affinity of small molecules to specific biological targets are of special interest because they can accelerate the discovery of new hit compounds.

In this study, we compared the ability of AD4 and Vina to identify ligands by ranking the relative binding affinity of small molecules.

First, a description of the methods employed to define viral inhibition and the binding affinity of small molecules is required.

ESI-TOF-MS is a powerful tool for directly observing the binding affinity of small molecules with biomolecules such as DNA and RNA.

These data show for the first time the ability to modulate the binding affinity of small-molecule probes with a JHDM by only modifying their "methylation state".

Computational methods to predict binding affinities of small ligands toward relevant biological (off- targets are helpful in prioff- targetse screening are synthelpfulf new drug candinates, thereby sprioritizinghe drug discovery process.

Herein, we report the development of a homogeneous high-throughput assay based on fluorescence polarization for measuring the binding affinities of small-molecule inhibitors to the BIR3 domain of XIAP.

The technique has been particularly useful in screening and evaluating binding affinity of novel small molecule and biomolecule-derived therapeutics for various diseases and applications including lupus medications, thrombin inhibitors, HIV protease inhibitors, DNA gyrase inhibitors and many others.

The performance of several structure-based design (SBD) approaches in predicting the binding affinity of diverse small molecule inhibitors co-crystallized to human renin was assessed to ascertain the modeling tool and method of choice required when dealing with structure-based lead optimization projects.