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The binding affinity of several of tested compounds against Src SH2 domain correlates with antiproliferative activity in 293T cells.
A difference in Z33 binding affinity of several orders of magnitude was observed between human and bovine antibodies.
Moreover, recent studies have shown mixed binding affinity of several new PET tracers to the TSPO in humans, due to presence of a TSPO polymorphism [ 21, 22].
Our findings are also in agreement with a study examining binding affinity of several phytoestrogens to either ERα or ERβ; compared to the E2 standard (set as 100%), relative binding affinity of genistein, biochanin A, coumestrol, and diadzein were greater to ERβ than to ERα [ 64].
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The goal of this study was to characterize the NET transport kinetics and binding affinities of several sympathetic nerve radiotracers, including [11C]--meta-hydroxyephedrine, [11C]--epinephrine, and a series of [11C]-labeled phenethylguanidines under development in our laboratory.
Due to different binding mechanisms, the binding affinity of various TSPO radioligands may vary significantly.
Binding affinities of several polyaromatic hydrocarbons to mutagenically modified OBPs were measured in competitive binding assays.
Although searching for potential mechanisms for the actions of BPA and E2, we examined published values of their binding affinity to several putative receptors.
Several studies have attempted to determine the binding affinity of H1 to chromatin.
d'Alesio et al. (2005) detected that several SNPs are predicted to be related to genes by influencing the binding affinity of transcription factors in the promoter region.
The predicted binding affinity of identified inhibitor is higher than available inhibitors with a 100-fold selectivity towards Plk1 over Plk2-4 and several cell cycle kinases.
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