Sentence examples for binding affinity of particular from inspiring English sources
This allows the network to function as a toggle switch if the binding affinity of particular repressors is temporarily lowered.
Regarding TLS, PCNA mono-ubiquitylation enhances the binding affinity of particular DNA polymerases, called TLS polymerases (Pol- η, Rev1 and Pol- ζ in budding yeast), which are able to substitute the stalled replicative polymerases in a process called "polymerase switch" [ 39].
This revealed considerable variation in the binding affinities of particular pairs of interacting proteins (Figure 2).
To estimate the binding affinity of the particular PAB variants in solution, we used microscale thermophoresis (MST) with a fluorescently-labelled HisTag-PSP94 and measured interactions with PAB036, PAB046, and PAB050 variants.
In our model the binding affinity of a particular mismatch is independent of its position in the probe sequence.
In particular, the binding affinity of GS14dK4 varies markedly with the charge and to some extent with the polar headgroup structure of the phospholipid and with the cholesterol content of the model membrane.
Furthermore, this information can be exploited by experimental scientists to design better ligands for a particular receptor or for studying binding affinity of hormones to their corresponding receptors.
Well consistent with the above theoretical analysis, our result further suggested that the targeting specificity of the nanoscaled drug delivery systems for a particular cell type can be enhanced by the weaker binding affinity of each individual receptor-ligand pair.
Techniques from the signal-processing field were used, in particular the Hann digital filter, to calculate the relative binding affinity of different regions based on previously published in vitro binding data.
Our data also reveal that the binding affinity of UbcM2 for its cognate E3 ligase can impact ubiquitylation capacity as tighter binding under particular reaction conditions can promote polyUb chain formation.
In particular, we need mutations that perturb interdomain contact, exclusively, without perturbing the binding affinity of WW domain residues.
