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When these mono and bivalent molecules are tethered to a surface, the overall binding affinity of multiple glycans with influenza viruses is expected to increase exponentially, leading to a higher capturing efficiency.
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Finally, we compare the binding affinities of multiple kinase inhibitors with the phosphorylation activity of their targets in our study.
We proposed a model that operates with binding affinities of multiple transcriptional regulators of pluripotency, and the activity of an autocrine signaling pathway.
To describe a potential mechanism generating the experimentally observed dynamics, we proposed a model that operates with binding affinities of multiple transcriptional regulators of pluripotency, the topology of the transcriptional regulatory networks, and activity of an autocrine signaling pathway.
It has allowed measurement of the binding affinity of PRDs to multiple peptide sequences [3].
JNJ-26483327 has displayed binding affinity to multiple tyrosine kinase receptors known to play a role in a wide variety of neoplasms.
Using Surface Plasmon Resonance SPRR) studies, we observed that multiple phosphorylations significantly reduce the binding affinity of the peptides to the c-Cbl TKB, with the triply phosphorylated peptide having the lowest affinity amongst all the peptides tested.
The higher binding affinity of intact MV RNP relative to N peptide for HSP72 may be attributed to the multiple N monomers present within a given RNP fragment, all of which would participate in solid-phase HSP72 binding.
As it is possible that multiple receptors presented on the target cells may overcome the reduced binding affinity of mutated receptors, we examined strain Rd binding to I91A and Q89A/N-substituted receptors expressed in transiently transfected COS cells.
By following this rational design concept of targeting multiple structural water molecules as binding partners for small organic molecules, we could enhance the binding affinity of our rationally designed phthalimide scaffold by a factor of 20.
The multiple mono-ubiquitination of tau by the RING-variant domain of axotrophin suggests that the microtubule binding affinity of tau is affected by tau ubiquitination.
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CEO of Professional Science Editing for Scientists @ prosciediting.com