Sentence examples for binding affinity of insulin from inspiring English sources

However, HisB5 seems to be co-responsible for the low binding affinity of insulin for IGF-1R.

We also showed that L-Cit increased the phosphorylation of tyrosine in IRS1, which is upstream of Akt, and this was not related to the binding affinity of insulin to its receptor or the expression of the insulin receptor.

Yet, these small structural changes might also increase the binding affinity of insulin analogues towards the IGF1R and, consequently, increase the mitogenic potency of these molecules compared to regular insulin.

The binding affinity of insulin analogues to both IR and IGF1R and their subsequent activation and overall mitogenic capacity are currently used as part of the risk assessment in terms of carcinogenic potential of newly developed insulin analogues.

Initially it was thought that the high binding affinity of insulin glargine for insulin-like growth factor (IGF -1 receptors may adversely IGF -1 the preceptorsn of retinopathy in diabetic patients (Chakkarwar & mayjrekadversely

The L-Cit-induced enhancement in insulin signaling was not related to the binding affinity of insulin to the insulin receptor or to the expression of the insulin receptor, but to a decrease in the phosphorylation of serine 1101 in IRS-1.

An increased residence time as well as an increased binding affinity of synthetic insulin-like molecules towards IRA and especially IGF1R might affect carcinogenesis [ 2, 3].

L-Cit had no significant effect on the insulin binding affinities of the insulin receptor (Fig.  2).

The phosphorylation level and binding affinity to insulin of insulin receptors were significantly diminished in media with low pH [ 47].

[ d-ProB8]-insulin retained only 0.08% of the affinity of HI, and the binding affinity of [ NMeAlaB8]-insulin was under the range of our measurement (<0.01%).

In an in vitro study, the binding affinity of M1 and M2 to insulin receptors was similar to that of the parent compound, but they had lower affinity than insulin glargine for IGF-1 receptors in cells expressing these receptors [ 60].