Sentence examples for binding affinity of compounds from inspiring English sources

When the fraction of enzyme in the open conformation is taken into account, the "intrinsic binding affinity" of compounds that bind in the NAD site can be considerably greater than the observed binding affinity (Table 5).

Docking simulations showed comparable binding affinity of compounds 3 and 4 with AChE enzyme.

The introduction of substituted amine side chain at quinolinium obviously increased the binding affinity of compounds to G-quadruplex DNA.

Shamsuzzaman et al. synthesized some steroidal pyrimidines for interaction with DNA and indicated higher binding affinity of compounds towards DNA [46].

Thus, the built QSAR model can be used to fast and accurately predict the binding affinity of compounds (in the defined applicability domain) to TRβ1.

All the structures were docked to colchicine binding site of β tubulin for examining the binding affinity of compounds for antitumor activity.

The compounds bind to DNA preferentially through electrostatic and hydrophobic interactions with Kb; 1.8 × 104 M−1, 2.2 × 104 M−1 and 2.6 × 104 M−1, respectively, indicating the higher binding affinity of compound 6 towards DNA.

All of them contribute to fix the ligand in the forward mode and to stabilize the tetramer explaining the superior binding affinity of compound 23b over 22b ([EC50 (T4)/EC50 (23b) = 3.4] vs. [EC50 (T4)/EC50 (22b) = 0.95], see Figure 6 and Figure 7).

The binding affinity of compound 10 to sGCcat was explored in detail using SPR, and suggests a 1 1 interaction between the compound and the dimer, with a calculated KD of 11.4 ± 1.8 μM (Fig. 6).

This analysis indicated that binding affinity of compound 33RE to C- and N-domains, and therefore N-selectivity, is in the same range as that of the parent molecule.

This confirmed the capability of PPR for the prediction of the binding affinities of compounds.