Sentence examples for binding affinity of compound from inspiring English sources
The compounds bind to DNA preferentially through electrostatic and hydrophobic interactions with Kb; 1.8 × 104 M−1, 2.2 × 104 M−1 and 2.6 × 104 M−1, respectively, indicating the higher binding affinity of compound 6 towards DNA.
All of them contribute to fix the ligand in the forward mode and to stabilize the tetramer explaining the superior binding affinity of compound 23b over 22b ([EC50 (T4)/EC50 (23b) = 3.4] vs. [EC50 (T4)/EC50 (22b) = 0.95], see Figure 6 and Figure 7).
This analysis indicated that binding affinity of compound 33RE to C- and N-domains, and therefore N-selectivity, is in the same range as that of the parent molecule.
The binding affinity of compound 10 to sGCcat was explored in detail using SPR, and suggests a 1 1 interaction between the compound and the dimer, with a calculated KD of 11.4 ± 1.8 μM (Fig. 6).
When the fraction of enzyme in the open conformation is taken into account, the "intrinsic binding affinity" of compounds that bind in the NAD site can be considerably greater than the observed binding affinity (Table 5).
Thus, the built QSAR model can be used to fast and accurately predict the binding affinity of compounds (in the defined applicability domain) to TRβ1.
In this paper, an accurate and reliable QSAR model of 87 selective ligands for the thyroid hormone receptor β 1 (TRβ1) was developed, based on theoretical molecular descriptors to predict the binding affinity of compounds with receptor.
Shamsuzzaman et al. synthesized some steroidal pyrimidines for interaction with DNA and indicated higher binding affinity of compounds towards DNA [46].
