Sentence examples for binding affinity of chemicals from inspiring English sources
These studies may help to understand the factors influencing the binding affinity of chemicals and to develop alternative methods for prescreening and designing of polo-like kinase inhibitors.
Most of these assays fall into one of three categories: a) ER competitive binding assays that measure the binding affinity of a chemical for the ER; b) reporter gene assays that measure ER binding-dependent transcriptional and translational activity and c) cell proliferation assays that measure the rate of increase in the number of target cells during the exponential phase of proliferation [ 32].
The molecular modeling of the ergoline-skeleton is based on the comprehensive theoretical study of the binding affinity of the isolated chemicals towards the active sites of the D3 sub-type receptor (D3R) loops.
A novel competitive binding assay based on enzyme fragmentation complementation technology was established to screen the binding affinities of emerging chemicals for estrogen receptor (ER) α or β isoforms.
The major factors influence the binding affinity of steroids and non-steroidal chemicals were electrostatic and hydrophobic interactions, respectively.
This system would be able to help us confirm the binding affinity of candidate genes to the chemicals emitted by the host plant.
Notably, the ultra-affinity concept proposed here shares some similarities with the well-known kinetic proofreading (Hopfield, 1974) since in both cases chemical energy consumption is used to increase the binding affinity of specific molecules beyond their equilibrium value.
Thus, competing binding affinity of OH-PCBs versus T4 might be a potential pathway to transport these hazardous chemicals to the brain, which may lead to subsequent impacts on neurodevelopment.
A group of chemicals showed the more inhibitory effect on human cancer cells, and we evaluated the binding affinity of BIR3 domain.
Receptor-based virtual screens seek to "dock" members of a chemical library against a given protein structure, predicting the conformation and binding affinity of the small molecules [2].
The binding affinity of various cephalosporins to the PBPs of Gram-negative organisms varies by cephalosporin, and the chemical structure of ceftazidime is such that it is primarily an inhibitor of PBP3 of Gram-negative bacteria, including P. aeruginosa.
