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Here, we exhaustively analyse 1,137 complete landscapes from 129 eukaryotic species, each describing the binding affinity of a transcription factor to all possible short DNA sequences.
The shape of this distribution tells how much the beads are aggregating, and thus indicates the binding affinity of a protein to a receptor.
Similarly, mutation of threonine 168 to either valine or glutamate did not significantly alter the binding affinity of a catalytically inactive XCL100 protein for active p42 MAPK in vivo.
The binding affinity of a drug for soluble tubulin heterodimers is a common and relatively readily determined biochemical characteristic of a tubulin-targeted drug.
Computing the binding affinity of a protein ligand complex is one of the most fundamental and difficult tasks in computer-aided drug design.
Herein, we designed, synthesized and evaluated the binding affinity of a series of bitopic ligands: arypiperazine-phenyl-1,2,4-oxadiazoles.
We show that this flexibility is essential in order to correctly model the binding affinity of a set of diverse ligands.
Competitive ligand-binding assays measure the binding affinity of a substance to an (isolated) receptor.
The binding affinity of a given agonist towards its target GPCR depends on which state the receptor is in.
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For instance, one can compare the re-binding affinity of a synthesised EMIC using the TSA, against the theoretical adsorption affinity of that EMIC but imprinted with the TS.
The RNA-binding affinity of a complex of MLN51 SELOR and eIF4AIII is increased about 2-fold in the presence of ATP, but about 100-fold if Y14 and Magoh are also present.
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