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The relative effect of DNA shape on nucleosome stability versus homeodomain binding affinity may set in place a fine competitive balance for binding at these sites.
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Moreover, the BSA Cu2+ binding affinity may play an important role in the oxidation process of the LDL particles.
The higher binding affinity may explain why thallium could not replace sodium in the heavy-atom soaking experiment in GltPh (ref. 9).
Finally, the prediction of the corticosteroid-binding globulin binding affinity of steroids set was performed.
Affinity probe CE and fluorescence anisotropy assays demonstrate the binding affinity of a set of aptamer candidates identified through this bioinformatics approach.
Such a description further sheds light on the often observed low affinity binding: affinity measurements may not reflect in vivo scenarios.
To obtain the ligand binding affinity, a much larger set of simulations are required.
Using this multiple state approach, a binding affinity model was constructed for set of known hERG channel binders.
For each antigen, the binding affinity was predicted for a set of 10.000 random natural peptides using the NetMHCpan method.
Due to different binding mechanisms, the binding affinity of various TSPO radioligands may vary significantly.
If a cluster contains only low (resp. high) binding affinity peaks, the corresponding sequences may contain weak (resp. strong) binding motifs, i.e., motifs that are specific to low (resp. high) binding affinity.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com