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Thus, factors other than 2F5 binding affinity may have a critical role to play in the design of a 2F5-based vaccine.
MEC has also been used to explain the paradox that ESAs with lower receptor binding affinity may have higher in vivo activity.
Model-based simulations were employed to demonstrate and explain the paradoxical behavior that ESAs with lower receptor binding affinity may have higher in vivo activity.
A paradox resulting from EPO analogues developed through glycosylation is that analogues with lower receptor binding affinity may have higher in vivo activity.
It has been further used to explain the paradox that erythropoiesis-stimulating agent (ESA) with lower receptor binding affinity may have higher in vivo activity.
It is feasible that high levels of phytoestrogens, which have low potency (Table 1) and low estrogen receptor binding affinity, may have effectively inhibited activity in the YES by competing with potent estrogens for receptor binding sites.
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The repertoires of plant GHs, with their associated catalytic activities and polysaccharide binding affinities, may have valuable applications in modifying plant cell wall architecture and in the development and characterization of new bioenergy feedstocks.
In addition to having different biologic activities, binding affinity may skew interpretation of antibody target engagement studies in humans.
This binding mechanism is characterized by multiple weak binding sites that have fast off rates, such that when the number of binding moieties increases, the apparent binding affinity may also increase.
Moreover, the BSA Cu2+ binding affinity may play an important role in the oxidation process of the LDL particles.
Binding studies have demonstrated that the EPOR has different affinities for EPO and that EPOR isoforms with higher affinity for EPO may be responsible for the erythropoietic effects of EPO, whereas isoforms with a lower affinity for EPO binding may have nonerythropoietic effects, such as tissue protection [12].
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binding peptide may have
binding capability may have
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binding capacity may have
binding protein may have
binding affinity may skew
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