Sentence examples for binding affinity in which from inspiring English sources

We also designed argifin derivatives with better binding affinity, in which a constituent amino-acid residue of argifin was mutated to one with a bulky side chain.

Gunturi et al. [30] used a modification of the ANTSELECT algorithm in a recent study of human serum albumin binding affinity in which the number of features selected was fixed a priori and, in addition, could not include descriptors that had a correlation coefficient greater than 0.75.

This implies that target 5' XXXGGGXXX 3' binds to the same ZFP with higher binding affinity in comparison to the target 5' XXXGTAXXX 3' which binds with lower affinity to the same protein [ 30].

Also, molecular docking study was undertaken on E. histolytica thioredoxin reductase (EhTHRase) protein which showed significant binding affinity in the active site.

d Relative binding affinity in fold decrease in affinity compared to the HO(10) binding site.

Combined with the results observed in EMSA and ChIP assays, we thus conclude that the increased binding must be due to the increase of Sp1 DNA binding affinity, which in turn lead to the higher expression of p16INK4a in senescent cells.

These findings are confirmed by binding affinity calculations which are in good agreement with experiment.

A competitive ELISA confirmed specific binding of the purified antibodies to recombinant RAI3 in solution and was used to calculate binding affinity constants, which were all in the nanomolar range (Table 1).

Secondly, some predicted immunodominant T- and B-cell epitopes in the vaccine strain were not identified as epitopes in the field strains by the immuno-informatic tools, indicating a difference in their antigenicity or binding affinity to receptors, which, in turn, would affect the quality of the downstream immune cascade.

Saturated fatty acids decrease responsiveness of the cell membrane to insulin-mediated actions through a decrease in binding affinity, which contributes to increased insulin resistance (28).

Ames et al. [ 48] demonstrated that genetic diseases can reduce the binding affinity of enzymes, which in turn lowers the rate of metabolic reactions.