Sentence examples for binding affinity in the from inspiring English sources
Representative compounds tested using ITC were revealed to possess moderate binding affinity in the low micromolar range.
These different orientations of ligand inside the binding pocket of CB1 and CB2 receptors may explain its different binding affinity in the two receptors.
Also, molecular docking study was undertaken on E. histolytica thioredoxin reductase (EhTHRase) protein which showed significant binding affinity in the active site.
Notably, the binding affinity in the second ligand-occupation reaction showed the optimal value as a function of the ligand density.
In this study, the contributions to binding affinity in the CDR2 and CDR3 regions of two monoclonal antibodies E3.3 and 2H2 were investigated by random mutagenesis in a phage-display synthetic oligonucleotide library.
It is noteworthy that 2- 2-chlorophenyl -5-methyl-7- 4-methylpiperazin-1-yl) oxazolo[5,4-d]pyrimidine 47 and 2- 2-chlorophenyl -5-methyl-7- 4-methylpiperazin-1-ylloxazolo[5,4-d]pyrimidine 48 showed CB2- 2-chlorophenyl -5-methyl-7- 4-methylpiperazin-1-ylcant selectivity over CB1 receptors.
These agents exhibited higher progesterone receptor binding affinities in the nanomolar range and intracellular accumulation.
Truncated channels exhibit normal unitary conductances and anion selectivities but altered apparent anion binding affinities in the open and in the closed state.
Using a standard protein-ligand docking program with only minor modifications, four new ligands with binding affinities in the micromolar range were identified, including two compounds based on molecular scaffolds not resembling known ligands.
