Sentence examples for binding affinity in an from inspiring English sources

Next, we constructed several domain II loop mutant toxins and tested their binding affinity in an SPR analysis, and also performed a cell swelling assay to evaluate receptor-mediated cytotoxicity.

Comparison of binding affinity in an Aβ plate-based ELISA showed greater than 100-fold-higher affinity for fibrillar Aβ 1-42) than for monomeric Aβ 1-42) [ 208].

Other new TSPO radioligands reported include the phenoxyarylacetamides [C]DAA1106, [C]PBR28 or [F]PBR06, which have been claimed to perform better than [C]PK11195 for in vivo imaging of TSPO, based on higher binding affinity in an animal model of neuroinflammation [ 43] and high levels of specific binding in non-human primates and in human brain [ 44, 45].

The reagent shows a strong calcium binding affinity in a 1 1 ratio and metal selectivity in the order Ca2+>Mg2+>Sr2+≈K+≈Na+>Zn2+>Li+.

In addition, 12 amino acid residues (from Pro26 to Asn37) positioned in the extracellular region of N-terminus, were identified as a homophilic domain having binding affinity in a trans-interaction19.

However, how to evaluate T cell receptor binding affinity in a high-throughput fashion and decipher the interaction between the ligand repertoire and T cell receptor repertoire are still challenging.

The structure of the enzyme-inhibitor complex presents an opportunity to improve binding affinity in a novel series of inhibitors discovered by structure-based methods.

Molecular docking for the most potent compounds was performed to predict their possible binding mode within VEGFR2 active site and they showed binding affinity in a similar way to sorafenib.

Separately for each TF, we rank the promoter regions by their binding affinity in a decreasing order, such that the genes with high binding affinity are placed at the top of the list.

In this way, the conformational changes caused by repulsion of the protonated histidines 292 at the dimer interface are relayed to the ion-binding site to modulate the Na+ binding affinity in a pH-dependent manner.

For each bacterial tRNA species, the sequence of three base pairs in the T-stem modulates the protein binding affinity in a manner that offsets the variable affinity of the esterified amino acid such that the overall affinity of all aa-tRNAs are nearly uniform.