Sentence examples for binding affinity has a from inspiring English sources

A scoring function that would be able to perform perfect discrimination (i.e. no overlap between the two distributions of active and inactive compounds according to their calculated scores of binding affinity) has a ROC curve that passes through the upper left corner of the plot, where the TPF is 1 (perfect sensitivity) and the FPF is 0 (perfect specificity).

In contrast, mutant R22E, a partial CXCR3 agonist, but with markedly reduced GAG binding affinity, had a minimal effect on HUVEC proliferation even at the highest concentration tested.

β2-Integrins with high ligand binding affinity have an extended, open conformation where the cytoplasmic tails unclasp enabling the association of signalling molecules with the cytoplasmic domains that build the integrin adhesome.

In contrast, mutant R22E with markedly reduced GAG-binding affinity, had a minimal effect on HUVEC proliferation.

From the second binding event a binding affinity has been calculated, with a Kd of 0.6 µM.

Accurate prediction of binding affinities has been a central goal of computational chemistry for decades, yet remains elusive.

Thus, understanding the molecular basis for these different observed NikR−operon binding affinities has been a point of interest in this system.

BCRP substrates with the high binding affinities have common chemical structures, such as an azole ring [25], and quarternary nitrogen [26].   3.

It is possible that a change in MCAK microtubule binding affinity will have a counteracting effect on MCAK diffusion rate or the rate of tubulin removal at ends and that as a consequence.

It is possible that a change in MCAK microtubule binding affinity will have a counteracting effect on MCAK diffusion rate or the rate of tubulin removal at ends as previously shown (Cooper et al., 2010).

Kiss et al. extended the MEC concept by suggesting that an ESA with lower receptor binding affinity should have a higher MEC to ensure sufficient receptor binding.