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Thus, to achieve visualization of mGlu7 in the brain with PET, the development of novel ligand candidates with at least one order higher binding affinity for this receptor than MMPIP is required.
HBV-associated HzKR127 antibody displayed binding affinity for this structure at distances and strengths similar to those for the complex of the antibody with the full HBV (PDBID: 2EH8).
MAb 1EB2 had an intermediate binding affinity for this derivative when compared to full-length EBNA1, as seen in ELISA (data not shown).
The results demonstrated that there is at least an order of magnitude difference in these molecules' Kd values to α5β1 with VCN showing a higher binding affinity for this receptor (the average Kd values for integrin α5β1 were 15.2 nM for VCN, and 191.3 nM for native CN).
In addition, if their binding affinity for this simple sequence were higher, Smad proteins would decorate entire chromosomes.
The weak metal binding affinity for this variant results from clashing steric interactions within the metal coordination sphere.
Similar(46)
In addition, we find that reduction in binding affinity for the correct target within this pathway causes a proportional increase in misactivation of the related mating pheromone response pathway and that strong binding affinity alone does not guarantee efficient biological activity.
This is also consistent with the reported binding affinity for the catalytic metal.
This shows that the two enzymes have different binding affinity for the three substrates.
The tetradecapeptide bombesin (BN) shows high binding affinity for these BN2/GRP receptors.
This peptide, elaborated via phage display technology, reveals a high and specific binding affinity for the p++ Si material [13].
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