Sentence examples for binding affinity for rat from inspiring English sources

On the other hand these bifunctional ligands showed very weak and no binding affinity for rat brain bradykinin 2 receptors.

Six compounds, TASP0410457, TASP0434988, TASP0390136, TASP0390174, TASP0410426, and TASP0410427, were initially selected from our dihydroquinolinone compound library, since they fulfilled the following criteria for a PET radioligand candidate: (1) the presence of a methoxy group or other moieties for 11C or 18F labeling and (2) high binding affinity for rat H3R (IC50 < 3 nM).

The three compounds showed high in vitro binding affinity for rat and monkey H3Rs (Table 2) and displayed more than 60 times higher selectivity for H3R than off-target binding components including sigma 1, adrenergic α2c receptors, and 67 other molecules (Additional file 1: Table S1).

The comparison of each IgG binding affinity for rat AQP4-M23 in double dilution method.

No species differences in the binding affinity of compounds for M1ACh-R between various species including rat, primate and human have become apparent [59]; in this respect, it was found that the potency of AF150(S) to stimulate human M1ACh-R expressed in cells fully matches its binding affinity for M1ACh-R in rat brain homogenates (personal observations, manuscript in preparation).

c Targets detected with no significant binding affinity for CIS22a.

Moreover, the phosphorylation modification of FUNDC1 affects its binding affinity for LC3B and regulates selective mitophagy.

Bis-DOTA-hypericin had a selective binding affinity for PS and PE phospholipids [45].

The tetradecapeptide bombesin (BN) shows high binding affinity for these BN2/GRP receptors.

These VHHs were selected based on their specificity and binding affinity for their targets.

We show that type II binding can have a profound influence on binding affinity for CYP3A4, and the difference in binding affinity can be as high as 1200-fold.