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Similarly, CXCL10's strong heparin binding affinity could interfere with the binding of growth factors to GAGs, thereby not involving CXCR3.
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For SLII, the difference in binding affinity with or without U2A′ is small, such that U2A′ binding affinity could not be extracted from these experiments.
In this way, binding affinities could be estimated for compounds as weak as 30 mM.
While in vitro binding studies of transcription factors with differential binding affinities could be pursued, it has been well established that computational predictions of binding affinity are highly correlated with experimental measurements [ 56].
GABAAR scaffold-binding affinity could be regulated by PKC.
Interestingly, eEF1A is an actin/microtubule-binding protein and could interfere with BFA-induced apoptosis.
Thus, Lübker et al. [104] were able to show in vitro that PFOS, N-EtFOSA, N-EtFOSE, and PFOA could interfere with the binding affinity of the L-FABP to endogenous ligands (fatty acids), in the same manner as a strong peroxisome proliferator.
Alternatively, the low anti-HIV antibody titers in our treated population could interfere with binding to the control band.
We also assume that N- and C-terminal portions could interfere with the binding between full-length APIP12 and AvrPiz-t in yeast without known reasons.
Its in vivo activity study showed that compound Sysu-00692 could interfere with the binding between human POT1 and the telomeric DNA through chromatin immunoprecipitation.
Without antibody recognition, this proprietary reagent could interfere with the TFs by nonspecific binding of certain DNA binding proteins.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com