In addition, a change in the binding affinity could be caused by, for example, the presence of another histone modification at the same nucleosome, which could influence the stability of the interaction of the transferase with the nucleosome.
Similarly, CXCL10's strong heparin binding affinity could interfere with the binding of growth factors to GAGs, thereby not involving CXCR3.
For SLII, the difference in binding affinity with or without U2A′ is small, such that U2A′ binding affinity could not be extracted from these experiments.
In this way, binding affinities could be estimated for compounds as weak as 30 mM.
While in vitro binding studies of transcription factors with differential binding affinities could be pursued, it has been well established that computational predictions of binding affinity are highly correlated with experimental measurements [ 56].
GABAAR scaffold-binding affinity could be regulated by PKC.
The application to the bacterial multidrug efflux pump AcrB indicated that diffuse binding effects could cause 100-fold binding affinity for some ligands while little role in the binding of other ligands.
(B ) Conformational changes caused by the phosphorylation of Ft and Ds could provide an explanation for the differences in binding affinity caused by apparently similar phosphorylation events.
Furthermore, these reports demonstrated that minor structural modifications could cause a total loss of the binding affinity and/or the inhibitory activity of these compounds.
AgNPs stabilized with PTA could cause the strong affinity to GSH.
This matching score integrates the loss of binding affinity caused by both nucleotide and structure deviances from reference motif.
