These GBP-fusion proteins can directly bind onto the gold surface via the high binding affinity between the GBP and the gold surface, while at the same time, orient the recognition sites toward the sample for target binding.
Spectroscopic characterization indicated that MPHs are well distributed, with a strong binding affinity between the GO nanosheets.
The HLA type and peptide sequences from respective individuals were used to predict the binding affinity between the normal and the mutated peptide sequence using NetMHC38 which uses a machine learning algorithm to generate an affinity score.
This is explained by reducing the binding affinity between the siRNA strands to the complex, thereby enabling siRNA release after cellular internalization.
The COMBINE QSAR model highlights ∼20 interfacial residue pairs as responsible for most of the differences in binding affinity between the mutant complexes, mainly due to electrostatic interactions.
Docking studies were also performed and demonstrated that a reduction of the binding affinity between the drugs and HSA occurred in the presence of both drugs.
The binding affinity between the histone 3 (H3) tail and the ADD domain of ATRX ATRXADDD) increases with the subsequent addition of methyl groups on lysine 9 on H3.
Compared with most other reported non-functionalized conjugated microporous polymers, both of the bifunctionalized polymer networks show relatively high isosteric heat of CO2 adsorption (25 kJ mol−1) due to the introduction of the polar functional groups of sultone and hydroxy enhanced the binding affinity between the polymer networks and CO2 molecules.
The isosteric heats of carbon dioxide sorption for all of the polymer networks exceed 25 kJ/mol at the zero coverage because the introduction of silicon atom into the polymer skeleton enhanced the binding affinity between the adsorbent and CO2 molecules.
Molecular docking demonstrated that the addition of Mn2+ and Mg2+ into the active site of SMase improved the binding affinity between the SMase and sphingomyelin based on its free energy of binding as well as the interaction distances between the important catalytic residues Glu53 and His296.
The degradation rate constants of the PCBs decreased as binding free energy increased (i.e., the binding affinity between the ligand and receptor decreased) [19].
